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Kidney stones create intense, wave-like pain that typically starts in the back and radiates to the lower abdomen or groin

author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law

The consequences of this difference have been recognised in the investigation of the toxic mechanisms associated with gout, where the concentrations of UA that induce peripheral microcrystallisation and its related inflammatory reaction are not easily reached in rodents